HYPERSENSITIVITY TO ATROPINE

Cyclooxygense-1 inhibition delays hypersensitivity to nerve injury

Despite the important role of both cyclooxygenase (COX) isoforms (i.e. COX-1 and COX-2) in maintenance of hypersensitivity following peripheral nerve injury, their role in the development of neuropathic pain is not clear. The present study was undertaken to determine the effect of COX inhibitors to address the potential role of COX isozymes in the development of neuropathic pain in rats after c...

Hypersensitivity and cross-reactivity to cisplatin and carboplatin.

Cisplatin was the first of the platinum drugs. Second-generation platinum derivative was carboplatin that its efficacy in the treatment of many malignancies is equal to cisplatin, and its toxicity profile is more favorable. Here we report on a 50-year-old woman with a history of cervix cancer who developed a severe hypersensitivity reaction (HSR) to carboplatin. She was admitted to the emergenc...

Hypersensitivity Reaction to Local Anesthetic in Dentistry: A Case Report

Background and Aim: Local anesthesia plays an important role in dentistry. Although hypersensitivity reactions to local anesthetic drugs are rare,but they are more common in dental cartridge components. This study reports a rare case of hypersensitivity to components of local anesthesia cartridge. Case Report: A 61-year-old female patient referred to The Medical Council to complain the dentist ...

Immediate hypersensitivity and delayed hypersensitivity to clopidogrel.

Clopidogrel is a new antiplatelet prescribed for the secondary prevention of atherosclerotic events. The literature shows that the clinical manifestations of clopidogrel hypersensitivity include urticaria1, skin rash2-4, and angioedema5. The precise immunological mechanism underlying clopidogrel hypersensitivity has not been established. We describe two cases of hypersensitivity reaction due to...

Response to atropine in Down's syndrome.